The Journal of Experimental Medicine - Volume 206, issue 11

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Electronic ISSN
1540-9538
Print ISSN
0022-1007

Abstract

IL-6 alone induces IL-17 production in the absence of the Th1- and Th2-promoting transcription factors T-bet and STAT-6.

Contrary to popular belief, TGF-β doesn't directly induce Th17 cells. Here, Das et al. show that the cytokine merely paves the way for Th17s by blocking their antagonists
Journal: The Journal of Experimental Medicine, vol. 206, no. 11, 2009