The Journal of Experimental Medicine - Volume 203, issue 10

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Electronic ISSN
1540-9538
Print ISSN
0022-1007

Abstract

Like baby chicks, stem cells need a nest—a niche within the body where they reside and self-renew. Oguro et al. (page 2247) find that, for blood stem cells, this nest is built by the same gene silencer that also helps them self-renew.

Figure 1

Normal development of the bone marrow HSC nic

Journal: The Journal of Experimental Medicine, vol. 203, no. 10, 2006

Abstract

Genetic inactivation of Notch signaling in CD4CD8 double-negative (DN) thymocytes was previously shown to impair T cell receptor (TCR) gene rearrangement and to cause a partial block in CD4+CD8+ double-positive (DP) thymocyte development in mice. In c

Journal: The Journal of Experimental Medicine, vol. 203, no. 10, 2006