The Journal of Experimental Medicine - Volume 199, issue 5

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Electronic ISSN
1540-9538
Print ISSN
0022-1007

Abstract

Ig class switch recombination (CSR) requires expression of activation-induced deaminase (AID) and production of germline transcripts to target S regions for recombination. However, the mechanism of CSR remains unclear. Here we show that an extrachromosomal S plasmid assay is AID dependent and tha

Journal: The Journal of Experimental Medicine, vol. 199, no. 5, 2004