The Journal of Experimental Medicine - Volume 198, issue 7

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Electronic ISSN
1540-9538
Print ISSN
0022-1007

Abstract

During development, the stochastic process assembling the genes encoding antigen receptors invariably generates B and T lymphocytes that can recognize self-antigens. Several mechanisms have evolved to prevent the activation of these cells and the concomitant development of autoimmune disease. One

Journal: The Journal of Experimental Medicine, vol. 198, no. 7, 2003