The Journal of Experimental Medicine - Volume 195, issue 9

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Electronic ISSN
1540-9538
Print ISSN
0022-1007

Abstract

Deletion, anergy, and a spectrum of functional impairments can affect virus-specific CD8 cells in chronic viral infections. Here we characterize a low frequency population of CD8 cells present in chronic hepatitis B virus (HBV) infection which survive in the face of a high quantity of viral antig

Journal: The Journal of Experimental Medicine, vol. 195, no. 9, 2002

Abstract

CD22 is a B cell–specific transmembrane protein of the Siglec family. It binds specifically to α2,6-linked sialic acid (Sia) residues, which are also present on glycoproteins on the B cell surface. CD22 acts as a negative regulator in B cell receptor–mediated signaling by recruitment of Src homol

Journal: The Journal of Experimental Medicine, vol. 195, no. 9, 2002