The Journal of Experimental Medicine - Volume 192, issue 5

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Electronic ISSN
1540-9538
Print ISSN
0022-1007

Abstract

Tumor necrosis factor (TNF) signals cell death and simultaneously induces generation of ceramide. To evaluate the contribution of ceramide to TNF-dependent cell death, we generated clones of the TNF-sensitive cell line L929 that constitutively overexpress human acid ceramidase (AC). Ceramidase, i

Journal: The Journal of Experimental Medicine, vol. 192, no. 5, 2000