The Journal of Experimental Medicine - Volume 191, issue 8

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Electronic ISSN
1540-9538
Print ISSN
0022-1007

Abstract

Recent work has revealed correlations between bacterial or viral infections and atherosclerotic disease. One particular bacterium, Chlamydia pneumoniae, has been observed at high frequency in human atherosclerotic lesions, prompting the hypothesis that infectious agents may be necessary fo

Journal: The Journal of Experimental Medicine, vol. 191, no. 8, 2000

Abstract

Developing B cells undergo dramatic changes in their responses to chemoattractant cytokines (chemokines) and in expression of chemokine receptors. Bone marrow pre–pro-B cells (AA4.1+/natural killer 1.1 Fraction A cells) and cells capable of generating pro-B colonies in the

Journal: The Journal of Experimental Medicine, vol. 191, no. 8, 2000

Abstract

Immunoglobulin class switch recombination (SR) occurs by a B cell–specific, intrachromosomal deletional process between switch regions. We have developed a plasmid-based transient transfection assay for SR to test for the presence of transacting switch activities. The plasmids are novel in that t

Journal: The Journal of Experimental Medicine, vol. 191, no. 8, 2000