The Journal of Experimental Medicine - Volume 183, issue 4

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Electronic ISSN
1540-9538
Print ISSN
0022-1007

Abstract

Rearrangement of the immunoglobulin (Ig) and T cell receptor (TCR) gene loci allows for the generation of B and T lymphocytes with antigen- specific receptors. Complete rearrangement and expression of the TCR- beta chain enables immature thymocytes to differentiate from the CD4- CD8- to the CD4+C

Journal: The Journal of Experimental Medicine, vol. 183, no. 4, 1996