The Journal of Experimental Medicine - Volume 183, issue 2

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Electronic ISSN
1540-9538
Print ISSN
0022-1007

Abstract

P815 is a murine mastocytoma of DBA/2 origin which, although immunogenic, rapidly develops as a tumor in immunocompetent syngeneic hosts. In this report, we have studied, by a molecular approach, the in vivo alpha/beta T cell response to P815. Both situations of tumor growth after engraftment of

Journal: The Journal of Experimental Medicine, vol. 183, no. 2, 1996

Abstract

Zeta-associated protein (ZAP)-70 is a cytoplasmic protein tyrosine required for T cell antigen receptor (TCR) signaling and development. Mutations in ZAP-70 result in severe combined immunodeficiency in humans. ZAP-70 interacts with the TCR by binding to tyrosine- phosphorylated immunoreceptor ty

Journal: The Journal of Experimental Medicine, vol. 183, no. 2, 1996