The Journal of Experimental Medicine - Volume 181, issue 5

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Electronic ISSN
1540-9538
Print ISSN
0022-1007

Abstract

To study oncogenesis in the erythroid lineage, we have generated transgenic mice carrying the human c-MYC proto-oncogene under the control of mouse GATA-1 regulatory sequences. Six transgenic lines expressed the transgene and displayed a clear oncogenic phenotype. Of these, five developed an earl

Journal: The Journal of Experimental Medicine, vol. 181, no. 5, 1995