The Journal of Experimental Medicine - Volume 174, issue 5

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Cras neque tellus, ornare vel pulvinar luctus, vestibulum malesuada ante. Nullam pellentesque, ipsum vel fermentum tincidunt, velit neque molestie lacus, at iaculis purus mauris in nisl. Nullam vehicula imperdiet auctor. Mauris tempus, leo eget euismod condimentum, erat justo vehicula augue, vitae ornare elit felis nec libero. Etiam et quam sit amet metus dignissim dictum sed vitae purus. Phasellus gravida hendrerit risus vitae euismod. In elementum massa facilisis nulla pulvinar at pharetra leo pellentesque.

Electronic ISSN
1540-9538
Print ISSN
0022-1007

Abstract

Affinity chromatography and reverse-phase high-performance liquid chromatography was used to purify a soluble interleukin 1 beta (IL-1 beta) specific binding protein from the supernatant of a human B cell line, Raji. The purified protein specifically bound 125I IL-1 beta forming a 60-kD complex i

Journal: The Journal of Experimental Medicine, vol. 174, no. 5, 1991

Abstract

Previous studies have demonstrated that insulin, like other protein antigens, requires processing in metabolically active antigen- presenting cells (APC) before it can be recognized by class II- restricted T lymphocytes. Unlike many other proteins, insulin peptides of minimal size retain the requ

Journal: The Journal of Experimental Medicine, vol. 174, no. 5, 1991

Abstract

The accelerated autoimmune syndrome observed in BXSB/MpJ male mice is associated with the presence on the Y chromosome of an as yet unidentified mutant gene, designated Y chromosome-linked autoimmune acceleration (Yaa). To study the mechanisms by which the Yaa gene accelerates and/or induces the

Journal: The Journal of Experimental Medicine, vol. 174, no. 5, 1991