The Journal of Cell Biology - Volume 184, issue 1

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Electronic ISSN
1540-8140
Print ISSN
0021-9525

Abstract

Wang et al. provide new insights into how ceramide transfer protein (CERT) affects cell growth and survival.

Figure 1

CERT-deficient cells have swollen rough ER (black arrow) and distended or disintegrating mitochondria (white arrow).

CERT-deficient cells have swollen rough ER (

Journal: The Journal of Cell Biology, vol. 184, no. 1, 2009

Abstract

To maintain protein homeostasis in secretory compartments, eukaryotic cells harbor a quality control system that monitors protein folding and protein complex assembly in the endoplasmic reticulum (ER). Proteins that do not fold properly or integrate into cognate complexes are degraded by ER-assoc

Journal: The Journal of Cell Biology, vol. 184, no. 1, 2009