The Journal of Cell Biology - Volume 181, issue 2

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Electronic ISSN
1540-8140
Print ISSN
0021-9525

Abstract

Proliferation gets its own translation initiation factor, based on findings from Ramírez-Valle et al. The results help explain why that eIF is commonly overexpressed in breast cancers.

Figure 1

Breast cancer cells fill with autophagosomes (green) when eIF4GI is silenced.

Breast

Journal: The Journal of Cell Biology, vol. 181, no. 2, 2008

Abstract

The cellular events that precede myelination in the peripheral nervous system require rapid and dynamic morphological changes in the Schwann cell. These events are thought to be mainly controlled by axonal signals. But how signals on the axons are coordinately organized and transduced to promote

Journal: The Journal of Cell Biology, vol. 181, no. 2, 2008

Abstract

The MRE11–RAD50–Nijmegen breakage syndrome 1 (NBS1 [MRN]) complex accumulates at sites of DNA double-strand breaks (DSBs) in microscopically discernible nuclear foci. Focus formation by the MRN complex is dependent on MDC1, a large nuclear protein that directly interacts with phosphorylated H2AX.

Journal: The Journal of Cell Biology, vol. 181, no. 2, 2008