The Journal of Cell Biology - Volume 178, issue 6

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Electronic ISSN
1540-8140
Print ISSN
0021-9525

Abstract

Unstable microtubules create dense-boned mice, according to Gil-Henn et al. The authors show that bone-eating osteoclasts go hungry without the stabilizing activity of the Pyk2 tyrosine kinase.

In osteoclasts, Pyk2 resides mainly in podosomes, actin-rich structures that help attach osteocla

Journal: The Journal of Cell Biology, vol. 178, no. 6, 2007

Abstract

Sequestration of misfolded proteins into pericentriolar inclusions called aggresomes is a means that cells use to minimize misfolded protein-induced cytotoxicity. However, the molecular mechanism by which misfolded proteins are recruited to aggresomes remains unclear. Mutations in the E3 ligase p

Journal: The Journal of Cell Biology, vol. 178, no. 6, 2007