The Journal of Cell Biology - Volume 178, issue 3

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Electronic ISSN
1540-8140
Print ISSN
0021-9525

Abstract

Two key developmental proteins that once appeared to be molecular twins perform different jobs and work in different parts of the cell, as Geffers et al. show on page 465.

DLL1 (top) studs the surface of the cell, whereas DLL3 (bottom) collects in the interior.

Among its many function

Journal: The Journal of Cell Biology, vol. 178, no. 3, 2007

Abstract

Epithelial to mesenchymal transition (EMT) occurs during development and cancer progression to metastasis and results in enhanced cell motility and invasion. Transforming growth factor-β (TGF-β) induces EMT through Smads, leading to transcriptional regulation, and through non-Smad pathways. We ob

Journal: The Journal of Cell Biology, vol. 178, no. 3, 2007