The Journal of Cell Biology - Volume 177, issue 5

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Electronic ISSN
1540-8140
Print ISSN
0021-9525

Abstract

The uPA receptor (uPAR) is a loner. Jutting from the plasma membrane, it has no apparent connection to the cell interior. But, as Madsen et al. demonstrate on page 927, uPAR induces cells to cling tightly to a surface. The behavior might recruit other receptors and explain how the seemingly isola

Journal: The Journal of Cell Biology, vol. 177, no. 5, 2007

Abstract

The local accumulation of phosphatidylinositol (3,4,5) trisphosphate (PIP3) and resulting activation of Rac1/Cdc42 play a critical role in nerve growth factor (NGF)–induced neurite outgrowth. To further explore the mechanism, we visualized PIP3, phosphatidylinositol (3,4) bi

Journal: The Journal of Cell Biology, vol. 177, no. 5, 2007