The Journal of Cell Biology - Volume 176, issue 5

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Electronic ISSN
1540-8140
Print ISSN
0021-9525

Abstract

The extracellular signal–regulated kinase (ERK)–mitogen-activated protein kinase (MAPK) pathway provides a major link between the cell surface and nucleus to control proliferation and differentiation. However, its in vivo role in skeletal development is unknown. A transgenic approach was used to

Journal: The Journal of Cell Biology, vol. 176, no. 5, 2007

Abstract

The yeast endoplasmic reticulum (ER) membrane-localized chaperone Shr3 plays a critical role in enabling amino acid permeases (AAPs) to fold and attain proper structures required for functional expression at the plasma membrane. In the absence of Shr3, AAPs specifically accumulate in the ER, wher

Journal: The Journal of Cell Biology, vol. 176, no. 5, 2007