The Journal of Cell Biology - Volume 172, issue 5

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Cras neque tellus, ornare vel pulvinar luctus, vestibulum malesuada ante. Nullam pellentesque, ipsum vel fermentum tincidunt, velit neque molestie lacus, at iaculis purus mauris in nisl. Nullam vehicula imperdiet auctor. Mauris tempus, leo eget euismod condimentum, erat justo vehicula augue, vitae ornare elit felis nec libero. Etiam et quam sit amet metus dignissim dictum sed vitae purus. Phasellus gravida hendrerit risus vitae euismod. In elementum massa facilisis nulla pulvinar at pharetra leo pellentesque.

Electronic ISSN
1540-8140
Print ISSN
0021-9525

Abstract

The microtubule motor cytoplasmic dynein and its activator dynactin drive vesicular transport and mitotic spindle organization. Dynactin is ubiquitously expressed in eukaryotes, but a G59S mutation in the p150Glued subunit of dynactin results in the specific degeneration of motor neuro

Journal: The Journal of Cell Biology, vol. 172, no. 5, 2006

Abstract

Microtubules were seen first as static struts in EM images (see “Microtubules get a name” JCB 168:852) and then as polymers created from a defined protein component (see “The discovery of tubulin” JCB 169:552). It took a series of studies in the 1980s to emphasize that dynamics were

Journal: The Journal of Cell Biology, vol. 172, no. 5, 2006