The Journal of Cell Biology - Volume 169, issue 6

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Electronic ISSN
1540-8140
Print ISSN
0021-9525

Abstract

Extracellular stimuli that activate cell surface receptors modulate glucocorticoid actions via as yet unclear mechanisms. Here, we report that the guanine nucleotide-binding protein (G protein)–coupled receptor-activated WD-repeat Gβ interacts with the glucocorticoid receptor (GR), comigrates wit

Journal: The Journal of Cell Biology, vol. 169, no. 6, 2005

Abstract

During mitosis, the absence of Ran-GTPase pathway components at kinetochores leads to aberrant attachment of kinetochore fibers, disordered mitotic spindle assembly, and haphazard chromosome segregation at anaphase. To ensure that Ran complex proteins get where they need to be, Crm1—the Ran-GTP–b

Journal: The Journal of Cell Biology, vol. 169, no. 6, 2005

Abstract

Although lipid-dependent protein clustering in biomembranes mediates numerous functions, there is little consensus among membrane models on cluster organization or size. Here, we use influenza viral envelope protein hemagglutinin (HA0) to test the hypothesis that clustering results fro

Journal: The Journal of Cell Biology, vol. 169, no. 6, 2005