The Journal of Cell Biology - Volume 168, issue 7

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Electronic ISSN
1540-8140
Print ISSN
0021-9525

Abstract

The budding yeast S phase checkpoint responds to hydroxyurea-induced nucleotide depletion by preventing replication fork collapse and the segregation of unreplicated chromosomes. Although the block to chromosome segregation has been thought to occur by inhibiting anaphase, we show checkpoint-defe

Journal: The Journal of Cell Biology, vol. 168, no. 7, 2005

Abstract

Using fluorescent variants of Fas and FasL, we show that membrane FasL and Fas form supramolecular clusters that are of flexible shape, but nevertheless stable and persistent. Membrane FasL-induced Fas clusters were formed in caspase-8– or FADD-deficient cells or when a cytoplasmic deletion mutan

Journal: The Journal of Cell Biology, vol. 168, no. 7, 2005