The Journal of Cell Biology - Volume 166, issue 5

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Electronic ISSN
1540-8140
Print ISSN
0021-9525

Abstract

Ubiquitination directs the sorting of cell surface receptors and other integral membrane proteins into the multivesicular body (MVB) pathway. Cargo proteins are subsequently deubiquitinated before their enclosure within MVB vesicles. In Saccharomyces cerevisiae, Bro1 functions at a late st

Journal: The Journal of Cell Biology, vol. 166, no. 5, 2004

Abstract

Contiguity between the ER and the nuclear envelope means nuclear membrane proteins have a direct shot to their target. In fact, inner nuclear membrane (INM) proteins were thought to need only to diffuse to the nucleus, pass through the nuclear pore, and then be retained by nuclear-localized bindi

Journal: The Journal of Cell Biology, vol. 166, no. 5, 2004