The Journal of Cell Biology - Volume 157, issue 3

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Electronic ISSN
1540-8140
Print ISSN
0021-9525

Abstract

Akey step in ER-associated degradation (ERAD) is dislocation of the substrate protein from the ER into the cytosol to gain access to the proteasome. Very little is known about how this process is regulated, especially in the case of polytopic proteins. Using pulse-chase analysis combined with sub

Journal: The Journal of Cell Biology, vol. 157, no. 3, 2002

Abstract

Trophic factor deprivation (TFD)-induced apoptosis in sympathetic neurons requires macromolecular synthesis–dependent BAX translocation, cytochrome c (cyt c) release, and caspase activation. Here, we report the contributions of other intrinsic and extrinsic pathway signals to these

Journal: The Journal of Cell Biology, vol. 157, no. 3, 2002