The Journal of Cell Biology - Volume 148, issue 5

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Electronic ISSN
1540-8140
Print ISSN
0021-9525

Abstract

The mechanism of action of the oncogene bcl-2, a key regulator of the apoptotic process, is still debated. We have employed organelle-targeted chimeras of the Ca2+-sensitive photoprotein, aequorin, to investigate in detail the effect of Bcl-2 overexpression on intracellular Ca

Journal: The Journal of Cell Biology, vol. 148, no. 5, 2000

Abstract

This report investigated mechanisms responsible for failed Schwann cell myelination in mice that overexpress P0 (P0tg), the major structural protein of PNS myelin. Quantitative ultrastructural immunocytochemistry established that P0 protein was mistarge

Journal: The Journal of Cell Biology, vol. 148, no. 5, 2000