The Journal of Cell Biology - Volume 147, issue 5

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Electronic ISSN
1540-8140
Print ISSN
0021-9525

Abstract

Using biochemical assays to determine the activation state of Rho-like GTPases, we show that the guanine nucleotide exchange factor Tiam1 functions as a specific activator of Rac but not Cdc42 or Rho in NIH3T3 fibroblasts. Activation of Rac by Tiam1 induces an epithelial-like morphology with func

Journal: The Journal of Cell Biology, vol. 147, no. 5, 1999