The Journal of Cell Biology - Volume 147, issue 4

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Electronic ISSN
1540-8140
Print ISSN
0021-9525

Abstract

A screen for mutants of Saccharomyces cerevisiae secretory pathway components previously yielded sec34, a mutant that accumulates numerous vesicles and fails to transport proteins from the ER to the Golgi complex at the restrictive temperature (Wuestehube, L.J., R. Duden, A. Eun, S.

Journal: The Journal of Cell Biology, vol. 147, no. 4, 1999

Abstract

p53 is mutated in ∼50% of human cancers, whereas mutations of the related p73 gene are rare. p73 can activate p53-responsive promoters and induce apoptosis when overexpressed in certain p53-deficient tumor cells. We show that p73 isoforms, p73α and p73β, can each induce permanent growth arrest wi

Journal: The Journal of Cell Biology, vol. 147, no. 4, 1999