Retrovirology - Volume 9, issue Preprint

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Electronic ISSN
1742-4690

Abstract

Background

Tat-mediated activation of the HIV-1 promoter depends upon a proteasome-associated factor, PAAF1, which dissociates 26S proteasome to produce 19S RP that is essential for transcriptional elongation. The effect of PAAF1 on proteasome activity could also potentially shield certain factors

Journal: Retrovirology, vol. 9, no. Preprint, 2012

Abstract

Background

RNase H is an endonuclease that hydrolyzes the RNA strand in RNA/DNA hybrids. Retroviral reverse transcriptases harbor a C-terminal RNase H domain whose activity is essential for viral replication. The RNase H degrades the viral genomic RNA after the first DNA strand is synthesized. Her

Journal: Retrovirology, vol. 9, no. Preprint, 2012