Respiratory Research - Volume 12, issue 1

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Electronic ISSN
1465-993X
Print ISSN
1465-9921

Abstract

Background

Our phase III clinical trial of pirfenidone for patients with idiopathic pulmonary fibrosis (IPF) revealed the efficacy in reducing the decline of vital capacity (VC) and increasing the progression-free survival (PFS) time by pirfenidone. Recently, marginal decline in forced VC (FVC) ha

Journal: Respiratory Research, vol. 12, no. 1, 2011

Abstract

Background

KL-6 is a mucin-like glycoprotein expressed on the surface of alveolar type II cells. Elevated concentrations of KL-6 in serum and epithelial lining fluid (ELF) in patients with acute respiratory distress syndrome (ARDS) have been previously reported; however, kinetics and prognostic si

Journal: Respiratory Research, vol. 12, no. 1, 2011

Abstract

Background

Declined lung function is a risk factor for particulate matter associated respiratory diseases like asthma and chronic obstructive pulmonary disease (COPD). Carbon nanoparticles (CNP) are a prominent component of outdoor air pollution that causes pulmonary toxicity mainly through inflam

Journal: Respiratory Research, vol. 12, no. 1, 2011