PLoS ONE - Volume 7, issue 4

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Electronic ISSN
1932-6203

Abstract

There is increasing evidence that breast and other cancers originate from and are maintained by a small fraction of stem/progenitor cells with self-renewal properties. Recent molecular profiling has identified six major subtypes of breast cancer: basal-like, ErbB2-overexpressing, normal breast ep

Journal: PLoS ONE, vol. 7, no. 4, 2012

Abstract

Enchytraeus albidus (Oligochaeta) is an ecologically relevant species used as standard test organisms for risk assessment. Effects of stressors in this species are commonly determined at the population level using reproduction and survival as endpoints. The assessment of transcriptomic res

Journal: PLoS ONE, vol. 7, no. 4, 2012

Abstract

Background

Small molecules have been shown to modulate the neurogenesis processes. In search for new therapeutic drugs, the herbs used in traditional medicines for neurogenesis are promising candidates.

Methodology and Principal Findings

We selected a total of 45 natural compounds from Tradit

Journal: PLoS ONE, vol. 7, no. 4, 2012

Abstract

Background

ATP-binding cassette (ABC) transporters are essential regulators of organismic homeostasis, and are particularly important in protecting the body from potentially harmful exogenous substances. Recently, an increasing number of in vitro observations have indicated a functional rol

Journal: PLoS ONE, vol. 7, no. 4, 2012

Abstract

Regulatory T-cells (Tregs) are a subset of CD4+ T-cells that have been found to suppress the immune response. During HIV viral infection, Treg activity has been observed to have both beneficial and deleterious effects on patient recovery; however, the extent to which this is regulated

Journal: PLoS ONE, vol. 7, no. 4, 2012

Abstract

This study assessed the efficacy of using visual and auditory biofeedback while immersed in a tridimensional videogame to practice a stress management skill (tactical breathing). All 41 participants were soldiers who had previously received basic stress management training and first aid training

Journal: PLoS ONE, vol. 7, no. 4, 2012

Abstract

The issue of large-scale testing has caught much attention with the advent of high-throughput technologies. In genomic studies, researchers are often confronted with a large number of tests. To make simultaneous inference for the many tests, the false discovery rate (FDR) control provides a pract

Journal: PLoS ONE, vol. 7, no. 4, 2012

Abstract

Bluetongue virus (BTV) can infect most species of domestic and wild ruminants causing substantial morbidity and mortality and, consequently, high economic losses. In 2006, an epizootic of BTV serotype 8 (BTV-8) started in northern Europe that caused significant disease in cattle and sheep before

Journal: PLoS ONE, vol. 7, no. 4, 2012

Abstract

While our understanding of the molecular and cellular aspects of taste reception and signaling continues to improve, the aberrations in these processes that lead to taste dysfunction remain largely unexplored. Abnormalities in taste can develop in a variety of diseases, including infections and a

Journal: PLoS ONE, vol. 7, no. 4, 2012

Abstract

The MutS2 homologues have received attention because of their unusual activities that differ from those of MutS. In this work, we report on the functional characteristics and conformational diversities of Thermotoga maritima MutS2 (TmMutS2). Various biochemical features of the protein were

Journal: PLoS ONE, vol. 7, no. 4, 2012