PLoS ONE - Volume 6, issue 12

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Electronic ISSN
1932-6203

Abstract

Introduction

Morbidity, mortality and social cost of sepsis are high. Previous studies have suggested that individual cytokines levels could be used as sepsis markers. Therefore, we assessed whether the multiplex technology could identify useful cytokine profiles in Emergency Department (ED) patie

Journal: PLoS ONE, vol. 6, no. 12, 2011

Abstract

There was an error in the name of the 13th author. The correct name is Florence Nguyen-Khac.

Journal: PLoS ONE, vol. 6, no. 12, 2011

Abstract

Map-based cloning and fine mapping to find genes of interest and marker assisted selection (MAS) requires good genetic maps with reproducible markers. In this study, we saturated the linkage map of the intra-gene pool population of common bean DOR364×BAT477 (DB) by evaluating 2,706 molecular mark

Journal: PLoS ONE, vol. 6, no. 12, 2011

Abstract

Women find masculinity in men's faces, bodies, and voices attractive, and women's preferences for men's masculine features are thought to be biological adaptations for finding a high quality mate. Fertility is an important aspect of mate quality. Here we test the phenotype-linked fertility hypoth

Journal: PLoS ONE, vol. 6, no. 12, 2011

Abstract

Cleavage factor IA (CF IA), cleavage and polyadenylation factor (CPF), constitute major protein complexes required for pre-mRNA 3′ end formation in yeast. The Clp1 protein associates with Pcf11, Rna15 and Rna14 in CF IA but its functional role remained unclear. Clp1 carries an evolutionarily cons

Journal: PLoS ONE, vol. 6, no. 12, 2011

Abstract

In the present study we report on the use of speed congenics to generate a C57BL/6J congenic line of HD-model R6/2 mice carrying 110 CAG repeats, which uniquely exhibits minimal intergenerational instability. We also report the first identification of the R6/2 transgene insertion site. The relati

Journal: PLoS ONE, vol. 6, no. 12, 2011

Abstract

The mammalian target of the rapamycin (mTOR) pathway, which drives cell proliferation, is frequently hyperactivated in a variety of malignancies. Therefore, the inhibition of the mTOR pathway has been considered as an appropriate approach for cancer therapy. In this study, we examined the roles o

Journal: PLoS ONE, vol. 6, no. 12, 2011

Abstract

Photosynthetic biomass production rapidly declines in mesophilic cyanobacteria grown above their physiological temperatures largely due to the imbalance between degradation and repair of the D1 protein subunit of the heat susceptible Photosystem II reaction centers (PSIIRC). Here we show that sim

Journal: PLoS ONE, vol. 6, no. 12, 2011

Abstract

Background

The expression of the clonally variant virulence factor PfEMP1 mediates the sequestration of Plasmodium falciparum infected erythrocytes in the host vasculature and contributes to chronic infection. Non-cytoadherent parasites with a chromosome 9 deletion lack clag9, a gene

Journal: PLoS ONE, vol. 6, no. 12, 2011

Abstract

Background

The eukaryotic translation initiation factor eIF4E plays a key role in plant-potyvirus interactions. eIF4E belongs to a small multigenic family and three genes, eIF4E1, eIF4E2 and eIF(iso)4E, have been identified in tomato. It has been demonstrated that eIF4E-mediat

Journal: PLoS ONE, vol. 6, no. 12, 2011