PLoS ONE - Volume 5, issue 5

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Electronic ISSN
1932-6203

Abstract

Background

Presently melanoma still lacks adequate treatment options for metastatic disease. While melanoma is exceptionally challenging to standard regimens, it is suited for treatment with immunotherapy based on its immunogenicity. Since treatment-related skin depigmentation is considered a favo

Journal: PLoS ONE, vol. 5, no. 5, 2010

Abstract

Basic-region leucine zipper (bZIP) proteins are one of the largest transcription factor families that regulate a wide range of cellular functions. Owing to the stability of their coiled coil structure leucine zipper (LZ) domains of bZIP factors are widely employed as dimerization motifs in protei

Journal: PLoS ONE, vol. 5, no. 5, 2010

Abstract

Background

Outbreaks of white spot disease have had a large negative economic impact on cultured shrimp worldwide. However, the pathogenesis of the causative virus, WSSV (whit spot syndrome virus), is not yet well understood. WSSV is a large enveloped virus. The WSSV virion has three structural la

Journal: PLoS ONE, vol. 5, no. 5, 2010

Abstract

Background

Clinically protective malaria vaccines consistently fail to protect adults and children in endemic settings, and at best only partially protect infants.

Methodology/Principal Findings

We identify and evaluate 1916 immunization studies between 1965-February 2010, and exclude partial

Journal: PLoS ONE, vol. 5, no. 5, 2010

Abstract

Neuronal calcium sensor-1 (NCS-1) is a Ca2+ sensor protein that has been implicated in the regulation of various aspects of neuronal development and neurotransmission. It exerts its effects through interactions with a range of target proteins one of which is interleukin receptor access

Journal: PLoS ONE, vol. 5, no. 5, 2010

Abstract

Streptococcus pneumoniae is the leading cause of respiratory acute infections around the world. In Latin America, approximately 20,000 children under 5 years of age die of pneumococcal diseases annually. Pneumococcal surface protein A (PspA) is among the best-characterized pneumococcal ant

Journal: PLoS ONE, vol. 5, no. 5, 2010

Abstract

During blastocyst formation the segregation of the inner cell mass (ICM) and trophectoderm is governed by the mutually antagonistic effects of the transcription factors Oct4 and Cdx2. Evidence indicates that suppression of Oct4 expression in the trophectoderm is mediated by Cdx2. Nonetheless, the

Journal: PLoS ONE, vol. 5, no. 5, 2010