PLoS ONE - Volume 5, issue 12

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Electronic ISSN
1932-6203

Abstract

Background and Purpose

17-O-acetylacuminolide (AA), a diterpenoid labdane, was isolated for the first time from the plant species Neouvaria foetida. The anti-inflammatory effects of this compound were studied both in vitro and in vivo.

Experimental Approach

Plant extracts were i

Journal: PLoS ONE, vol. 5, no. 12, 2010

Abstract

Information on the fine-scale movement of predators and their prey is important to interpret foraging behaviours and activity patterns. An understanding of these behaviours will help determine predator-prey relationships and their effects on community dynamics. For instance understanding a predat

Journal: PLoS ONE, vol. 5, no. 12, 2010

Abstract

Aeromonas hydrophila is the most common Aeromonas species causing infections in human and other animals such as amphibians, reptiles, fish and crustaceans. Pathogenesis of Aeromonas species have been reported to be associated with virulence factors such as lipopolysaccharides

Journal: PLoS ONE, vol. 5, no. 12, 2010

Abstract

Background

Generational IQ gains in the general population (termed the Flynn effect) show an erratic pattern across different nations as well as across different domains of intelligence (fluid vs crystallized). Gains of fluid intelligence in different countries have been subject to extensive resea

Journal: PLoS ONE, vol. 5, no. 12, 2010

Abstract

Background

In the process of protein evolution, sequence variations within protein families can cause changes in protein structures and functions. However, structures tend to be more conserved than sequences and functions. This leads to an intriguing question: what is the evolutionary mechanism by

Journal: PLoS ONE, vol. 5, no. 12, 2010

Abstract

In a previous study we proposed that the depolarized state of the wake-promoting hypocretin/orexin (hcrt/orx) neurons was independent of synaptic inputs as it persisted in tetrodotoxin and low calcium/high magnesium solutions. Here we show first that these cells are hyperpolarized when external s

Journal: PLoS ONE, vol. 5, no. 12, 2010

Abstract

Murine leukemia virus (MLV)-based retroviral vector is widely used for gene transfer. Efficient packaging of the genomic RNA is critical for production of high-titer virus. Here, we report that expression of the insulin-like growth factor II mRNA binding protein 1 (IMP1) enhanced the production o

Journal: PLoS ONE, vol. 5, no. 12, 2010

Abstract

Only thirteen microRNAs are conserved between D. melanogaster and the mouse; however, conditional loss of miRNA function through mutation of Dicer causes defects in proliferation of premeiotic germ cells in both species. This highlights the potentially important, but uncharacterized, role

Journal: PLoS ONE, vol. 5, no. 12, 2010

Abstract

The affordability of next generation sequencing (NGS) is transforming the field of mutation analysis in bacteria. The genetic basis for phenotype alteration can be identified directly by sequencing the entire genome of the mutant and comparing it to the wild-type (WT) genome, thus identifying acq

Journal: PLoS ONE, vol. 5, no. 12, 2010