PLoS ONE - Volume 4, issue 3

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Electronic ISSN
1932-6203

Abstract

Background

Polycomb-group (PcG) and trithorax-group (trxG) proteins regulate histone methylation to establish repressive and active chromatin configurations at target loci, respectively. These chromatin configurations are passed on from mother to daughter cells, thereby causing heritable changes i

Journal: PLoS ONE, vol. 4, no. 3, 2009

Abstract

The genetic structure of sheep reflects their domestication and subsequent formation into discrete breeds. Understanding genetic structure is essential for achieving genetic improvement through genome-wide association studies, genomic selection and the dissection of quantitative traits. After ide

Journal: PLoS ONE, vol. 4, no. 3, 2009

Abstract

Background

Cysteine (Cys) and its disulfide, cystine (CySS) represent the major extracellular thiol/disulfide redox control system. The redox potential (Eh) of Cys/CySS is centered at approximately −80 mV in the plasma of healthy adults, and oxidation of Eh Cys/CySS is implic

Journal: PLoS ONE, vol. 4, no. 3, 2009

Abstract

Using sample-matched transcriptomics and proteomics measurements it is now possible to begin to understand the impact of post-transcriptional regulatory programs in Enterobacteria. In bacteria post-transcriptional regulation is mediated by relatively few identified RNA-binding protein factors inc

Journal: PLoS ONE, vol. 4, no. 3, 2009

Abstract

Background

Previous studies have extensively documented antimicrobial and chemotactic activities of beta-defensins. Human beta-defensin-2 (hBD-2) is strongly expressed in lesional psoriatic epidermis, and recently we have shown that high beta-defensin genomic copy number is associated with psorias

Journal: PLoS ONE, vol. 4, no. 3, 2009

Abstract

Background

It has been shown that mutations in at least four myotubularin family genes (MTM1, MTMR1, 2 and 13) are causative for human neuromuscular disorders. However, the pathway and regulative mechanism remain unknown.

Methodology/Principal Findings

Here, we reported a

Journal: PLoS ONE, vol. 4, no. 3, 2009

Abstract

The mechanism of lamellipod actin turnover is still under debate. To clarify the intracellular behavior of the recently-identified actin disruption mechanism, we examined kinetics of AIP1 using fluorescent single-molecule speckle microscopy. AIP1 is thought to cap cofilin-generated actin barbed e

Journal: PLoS ONE, vol. 4, no. 3, 2009

Abstract

GPR3 is an orphan G protein-coupled receptor endowed with constitutive Gs signaling activity, which is expressed broadly in the central nervous system, with maximal expression in the habenula. We investigated the consequences of its genetic deletion in several behavioral paradigms and on neurotra

Journal: PLoS ONE, vol. 4, no. 3, 2009

Abstract

Background

The Mediterranean fruit fly Ceratitis Capitata (DIPTERA: Tephritidae) is a major agricultural pest in Argentina. One main cause for the success of non-contaminant control programs based on genetic strategies is compatibility between natural and laboratory germplasms.

A comp

Journal: PLoS ONE, vol. 4, no. 3, 2009