PLoS ONE - Volume 4, issue 11

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Electronic ISSN
1932-6203

Abstract

Channelrhodopsin-2 (ChR2), one of the archea-type rhodopsins from green algae, is a potentially useful optogenetic tool for restoring vision in patients with photoreceptor degeneration, such as retinitis pigmentosa. If the ChR2 gene is transferred to retinal ganglion cells (RGCs), which send visu

Journal: PLoS ONE, vol. 4, no. 11, 2009

Abstract

Background

The recent emergence of a novel pandemic influenza A(H1N1) strain in humans exemplifies the rapid and unpredictable nature of influenza virus evolution and the need for effective therapeutics and vaccines to control such outbreaks. However, resistance to antivirals can be a formidable p

Journal: PLoS ONE, vol. 4, no. 11, 2009

Abstract

Computational methods for determining the function of genes in newly sequenced genomes have been traditionally based on sequence similarity to genes whose function has been identified experimentally. Function prediction methods can be extended using gene context analysis approaches such as examin

Journal: PLoS ONE, vol. 4, no. 11, 2009

Abstract

Background

Poly(A) polymerase is a key enzyme in the machinery that mediates mRNA 3′ end formation in eukaryotes. In plants, poly(A) polymerases are encoded by modest gene families. To better understand this multiplicity of genes, poly(A) polymerase-encoding genes from several other plants, as wel

Journal: PLoS ONE, vol. 4, no. 11, 2009