PLoS ONE - Volume 3, issue 10

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Electronic ISSN
1932-6203

Abstract

A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, in particular a large number of loci derived from recent genome wide association studies (GWAS). True complex disease-associated loci often exert modest effects, so t

Journal: PLoS ONE, vol. 3, no. 10, 2008

Abstract

In mammals, the circadian clock relies on interlocked feedback loops involving clock genes and their protein products. Post-translational modifications control intracellular trafficking, functionality and degradation of clock proteins and are keys to the functioning of the clock as recently exemp

Journal: PLoS ONE, vol. 3, no. 10, 2008

Abstract

Background

Understanding of the magnitude and direction of the exchange of individuals among geographically separated subpopulations that comprise a metapopulation (connectivity) can lead to an improved ability to forecast how fast coral reef organisms are likely to recover from disturbance events

Journal: PLoS ONE, vol. 3, no. 10, 2008

Abstract

Background

Studies of wild animals responding to their native parasites are essential if we are to understand how the immune system functions in the natural environment. While immune defence may bring increased survival, this may come at a resource cost to other physiological traits, including rep

Journal: PLoS ONE, vol. 3, no. 10, 2008

Abstract

Background

Fluid and effective social communication requires that both face identity and emotional expression information are encoded and maintained in visual short-term memory (VSTM) to enable a coherent, ongoing picture of the world and its players. This appears to be of particular evolutionary

Journal: PLoS ONE, vol. 3, no. 10, 2008

Abstract

Background

Recent studies have associated the transcription factors, Oct4, Sox2 and Nanog as parts of a self-regulating network which is responsible for maintaining embryonic stem cell properties: self renewal and pluripotency. In addition, mutual antagonism between two of these and other master r

Journal: PLoS ONE, vol. 3, no. 10, 2008

Abstract

Background

Prolonged neonatal exposure to hyperoxia is associated with high mortality, leukocyte influx in airspaces, and impaired alveolarization. Inhibitors of type 4 phosphodiesterases are potent anti-inflammatory drugs now proposed for lung disorders. The current study was undertaken to determ

Journal: PLoS ONE, vol. 3, no. 10, 2008