Nucleic Acids Research - Volume 40, issue 9

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Electronic ISSN
1362-4962
Print ISSN
0305-1048

Abstract

Mdc1 is a large modular phosphoprotein scaffold that maintains signaling and repair complexes at double-stranded DNA break sites. Mdc1 is anchored to damaged chromatin through interaction of its C-terminal BRCT-repeat domain with the tail of γH2AX following DNA damage, but the role of the N-termi

Journal: Nucleic Acids Research, vol. 40, no. 9, 2012

Abstract

Non-canonical guanine quadruplex structures are not only predominant but also conserved among bacterial and mammalian promoters. Moreover recent findings directly implicate quadruplex structures in transcription. These argue for an intrinsic role of the structural motif and thereby posit that sin

Journal: Nucleic Acids Research, vol. 40, no. 9, 2012

Abstract

MicroRNAs (miRNAs) are a class of RNAs that play important regulatory roles in the cell. The detection of microRNA has attracted significant interest recently, as abnormal miRNA expression has been linked to cancer and other diseases. Here, we present a straightforward method for isothermal ampli

Journal: Nucleic Acids Research, vol. 40, no. 9, 2012