Nucleic Acids Research - Volume 39, issue 5

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Electronic ISSN
1362-4962
Print ISSN
0305-1048

Abstract

Immuno-precipitation of protein–DNA complexes followed by microarray hybridization is a powerful and cost-effective technology for discovering protein–DNA binding events at the genome scale. It is still an unresolved challenge to comprehensively, accurately and sensitively extract binding event i

Journal: Nucleic Acids Research, vol. 39, no. 5, 2010

Abstract

The visual detection of specific double-stranded DNA sequences possesses great potential for the development of diagnostics. Zinc finger domains provide a powerful scaffold for creating custom DNA-binding proteins that recognize specific DNA sequences. We previously demonstrated sequence-enabled

Journal: Nucleic Acids Research, vol. 39, no. 5, 2010