Nucleic Acids Research - Volume 39, issue 14

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Electronic ISSN
1362-4962
Print ISSN
0305-1048

Abstract

Recent studies indicate that the DNA recognition domain of transcription activator-like (TAL) effectors can be combined with the nuclease domain of FokI restriction enzyme to produce TAL effector nucleases (TALENs) that, in pairs, bind adjacent DNA target sites and produce double-strand breaks be

Journal: Nucleic Acids Research, vol. 39, no. 14, 2011

Abstract

The crystal structure of a Z-DNA hexamer duplex d(CGCGCG)2 determined at ultra high resolution of 0.55 Å and refined without restraints, displays a high degree of regularity and rigidity in its stereochemistry, in contrast to the more flexible B-DNA duplexes. The estimations of standar

Journal: Nucleic Acids Research, vol. 39, no. 14, 2011