Nucleic Acids Research - Volume 39, issue 12

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Electronic ISSN
1362-4962
Print ISSN
0305-1048

Abstract

The knowledge that potential guanine quadruplex sequences (PQs) are non-randomly distributed in relation to genomic features is now well established. However, this is for a general potential quadruplex motif which is characterized by short runs of guanine separated by loop regions, regardless of

Journal: Nucleic Acids Research, vol. 39, no. 12, 2011

Abstract

DNA methylation, an essential regulator of transcription and chromatin structure, is established and maintained by the coordinated action of three DNA methyltransferases: DNMT1, DNMT3A and DNMT3B, and the inactive accessory factor DNMT3L. Disruptions in DNMT3B function are linked to carcinogenesi

Journal: Nucleic Acids Research, vol. 39, no. 12, 2011

Abstract

Post-translational poly(ADP-ribosyl)ation has diverse essential functions in the cellular response to DNA damage as it contributes to avid DNA damage detection and assembly of the cellular repair machinery but extensive modification eventually also induces cell death. While there are 17 human pol

Journal: Nucleic Acids Research, vol. 39, no. 12, 2011