Nucleic Acids Research - Volume 37, issue 8

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Electronic ISSN
1362-4962
Print ISSN
0305-1048

Abstract

Mitochondrial DNA (mtDNA) is located in close proximity of the respiratory chains, which are the main cellular source of reactive oxygen species (ROS). ROS can induce oxidative base lesions in mtDNA and are believed to be an important cause of the mtDNA mutations, which accumulate with aging and

Journal: Nucleic Acids Research, vol. 37, no. 8, 2009

Abstract

The transcriptional program for a gene consists of the promoter necessary for recruiting RNA polymerase along with neighboring operator sites that bind different activators and repressors. From a synthetic biology perspective, if the DNA-binding specificity of these proteins can be changed, then

Journal: Nucleic Acids Research, vol. 37, no. 8, 2009