Nucleic Acids Research - Volume 36, issue 9

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Electronic ISSN
1362-4962
Print ISSN
0305-1048

Abstract

DNA double-strand breaks (DSBs) represent the most toxic DNA damage arisen from endogenous and exogenous genotoxic stresses and are known to be repaired by either homologous recombination or nonhomologous end-joining processes. Although many proteins have been identified to participate in either

Journal: Nucleic Acids Research, vol. 36, no. 9, 2008

Abstract

The Rag1 and Rag2 proteins initiate V(D)J recombination by introducing site-specific DNA double-strand breaks. Cleavage occurs by nicking one DNA strand, followed by a one-step transesterification reaction that forms a DNA hairpin structure. A similar reaction allows Rag transposition, in which t

Journal: Nucleic Acids Research, vol. 36, no. 9, 2008