Nucleic Acids Research - Volume 36, issue 13

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Electronic ISSN
1362-4962
Print ISSN
0305-1048

Abstract

Today's proteome is the result of innumerous gene duplication, mutagenesis, drift and selection processes. Whereas random mutagenesis introduces predominantly only gradual changes in protein function, a case can be made that an abrupt switch in function caused by single amino acid substitutions w

Journal: Nucleic Acids Research, vol. 36, no. 13, 2008

Abstract

Large-scale copy number variants (CNVs) have recently been recognized to play a role in human genome variation and disease. Approaches for analysis of CNVs in small samples such as microdissected tissues can be confounded by limited amounts of material. To facilitate analyses of such samples, who

Journal: Nucleic Acids Research, vol. 36, no. 13, 2008