Nucleic Acids Research - Volume 33, issue 22

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Electronic ISSN
1362-4962
Print ISSN
0305-1048

Abstract

DNA ligases are important enzymes which catalyze the joining of nicks between adjacent bases of double-stranded DNA. NAD+-dependent DNA ligases (LigA) are essential in bacteria and are absent in humans. They have therefore been identified as novel, validated and attractive drug targets

Journal: Nucleic Acids Research, vol. 33, no. 22, 2005