Journal of Biomedicine and Biotechnology - Volume 2012, issue Preprint

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Electronic ISSN
1110-7251
Print ISSN
1110-7243

Abstract

Regulatory sequences with endosperm specificity are essential for foreign gene expression in the desired tissue for both grain quality improvement and molecular pharming. In this study, promoters of seed storage α-kafirin genes coupled with signal sequence (ss) were isolated from Sorghu

Journal: Journal of Biomedicine and Biotechnology, vol. 2012, no. Preprint, 2012

Abstract

This study was designed to isolate the compounds responsible for the cytotoxic properties of South Indian Elephantopus scaber L. and further investigate their effects on quiescent and proliferating cells. Bioassay-guided isolation of the whole plant of chloroform extract of South Indian

Journal: Journal of Biomedicine and Biotechnology, vol. 2012, no. Preprint, 2012

Abstract

CDKN1C and NAP1L4 in human CDKN1C/KCNQ1OT1 imprinted domain are two key candidate genes responsible for BWS (Beckwith-Wiedemann syndrome) and cancer. In order to increase understanding of these genes in pigs, their cDNAs are characterized in this paper. By the IMpRH panel, porcine CDKN1C and NAP1

Journal: Journal of Biomedicine and Biotechnology, vol. 2012, no. Preprint, 2012

Abstract

CD24 is overexpressed in glioma cells in vitro and in vivo. However, the correlation of its expression with clinicopathological parameters of gliomas and its prognostic significance in this tumor remain largely unknown. To address this problem, 151 glioma specimens and 10 nonneoplas

Journal: Journal of Biomedicine and Biotechnology, vol. 2012, no. Preprint, 2012

Abstract

The module network method, a special type of Bayesian network algorithms, has been proposed to infer transcription regulatory networks from gene expression data. In this method, a module represents a set of genes, which have similar expression profiles and are regulated by same transcription fact

Journal: Journal of Biomedicine and Biotechnology, vol. 2012, no. Preprint, 2012

Abstract

Cystic fibrosis (CF) is a monogenic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, with lung and liver manifestations. Because of pitfalls of gene therapy, novel approaches for reconstitution of the airway epithelium and CFTR expression should be explored.

Journal: Journal of Biomedicine and Biotechnology, vol. 2012, no. Preprint, 2012

Abstract

Agouti-related protein (AgRP) is a 4-kDa cystine-knot peptide of human origin with four disulfide bonds and four solvent-exposed loops. The cell adhesion receptor integrin αvβ3 is an important tumor angiogenesis factor that determines the invasiveness and metas

Journal: Journal of Biomedicine and Biotechnology, vol. 2012, no. Preprint, 2012

Abstract

A novel vector with high gene delivery efficiency and special cell-targeting ability was developed using a good strategy that utilized low-molecular-weight polyethylenimine (PEI; molecular weight: 600 KDa [PEI600]) crosslinked to β-cyclodextrin (β-CyD) via a facile syn

Journal: Journal of Biomedicine and Biotechnology, vol. 2012, no. Preprint, 2012