Critical Care - Volume 10, issue 1

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Electronic ISSN
1466-609X
Print ISSN
1364-8535

Abstract

The use of controlled mechanical ventilation (CMV) in patients who experience weaning failure after a spontaneous breathing trial or after extubation is a strategy based on the premise that respiratory muscle fatigue (requiring rest to recover) is the cause of weaning failure. Recent evidence, ho

Journal: Critical Care, vol. 10, no. 1, 2005

Abstract

The PROWESS (Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis) trial demonstrated a 6.1% absolute decrease in mortality with a p value of 0.005. Despite the impressive results of this trial, criticism of the study has targeted various aspects of design, analysis

Journal: Critical Care, vol. 10, no. 1, 2006

Abstract

Introduction

Liver microcirculation disturbances are a cause of hepatic failure in sepsis. Increased leukocyte-endothelial interaction, platelet adherence and impaired microperfusion cause hepatocellular damage. The time course and reciprocal influences of ongoing microcirculatory events during en

Journal: Critical Care, vol. 10, no. 1, 2006