British Journal of Cancer - Volume 99, issue 5

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Electronic ISSN
1532-1827
Print ISSN
0007-0920

Abstract

Three phenotypically related genetic syndromes and their lesions (LKB1, PTEN, and TSC1/2) are identified as frequently altered in lung cancer. LKB1, a kinase inactivated in 30% of lung cancers, is discussed in this review. Loss of LKB1 regulation often coincident with KRAS ac

Journal: British Journal of Cancer, vol. 99, no. 5, 2008