British Journal of Cancer - Volume 84, issue 10

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Electronic ISSN
1532-1827
Print ISSN
0007-0920

Abstract

Prostatic steroid 5-alpha-reductase gene (SRD5A2) encodes a critical enzyme involved in the conversion of testosterone to dihydrotestosterone. A germline mis-sense substitution (A49T) leads to a variant SRD5A2 protein, which has a 5-fold higher in vitro V max than the wild-type

Journal: British Journal of Cancer, vol. 84, no. 10, 2001