British Journal of Cancer - Volume 104, issue 7

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Electronic ISSN
1532-1827
Print ISSN
0007-0920

Abstract

Background:

Uveal melanoma (UM) is the most common primary intraocular tumour of adults, frequently metastasising to the liver. Hepatic metastases are difficult to treat and are mainly unresponsive to chemotherapy. To investigate why UM are so chemo-resistant we explored the effect of interstrand

Journal: British Journal of Cancer, vol. 104, no. 7, 2011

Abstract

Background:

To investigate small-nucleolar RNAs (snoRNAs) as reference genes when measuring miRNA expression in tumour samples, given emerging evidence for their role in cancer.

Methods:

Four snoRNAs, commonly used for normalisation, RNU44, RNU48, RNU43 and RNU6B, and miRNA known to be associ

Journal: British Journal of Cancer, vol. 104, no. 7, 2011