British Journal of Cancer - Volume 102, issue 1

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Electronic ISSN
1532-1827
Print ISSN
0007-0920

Abstract

Background:

Owing to its role in cancer, the phosphoinositide 3-kinase (PI3K)/Akt pathway is an attractive target for therapeutic intervention. We previously reported that the inhibition of Akt by inositol 1,3,4,5,6-pentakisphosphate (InsP5) results in anti-tumour properties. To further

Journal: British Journal of Cancer, vol. 102, no. 1, 2010

Abstract

Background:

Loss of phosphatase and tensin homologue deleted in chromosome 10 (PTEN) function in advanced colorectal cancer (CRC) may represent one of the resistance mechanisms to cetuximab by interfering with the epidermal growth factor receptor signal transduction pathway.

Methods:

PTEN exp

Journal: British Journal of Cancer, vol. 102, no. 1, 2009