Breast Cancer Research - Volume 3, issue 1

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Electronic ISSN
1465-542X
Print ISSN
1465-5411

Abstract

BRCA1 and BRCA2 breast cancer susceptibility genes encode proteins, the normal cellular functions of which are complex and multiple, and germ-line mutations in individuals predispose both to breast and to ovarian cancer. There is nevertheless substantial evidence linking BRCA1 and B

Journal: Breast Cancer Research, vol. 3, no. 1, 2000

Abstract

Four trials of high-dose chemotherapy with stem cell support in breast cancer in the adjuvant and metastatic settings have shown no long-term disease-free or overall survival gain. This relative failure of a single high-dose therapy we believe opens up the development of a dose-dense approach wit

Journal: Breast Cancer Research, vol. 3, no. 1, 2000