BMC Genomics - Volume 9, issue Preprint

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Electronic ISSN
1471-2164

Abstract

Background

Trypanosomatids utilise polycistronic transcription for production of the vast majority of protein-coding mRNAs, which operates in the absence of gene-specific promoters. Resolution of nascent transcripts by polyadenylation and trans-splicing, together with specific rates of mRNA turnov

Journal: BMC Genomics, vol. 9, no. Preprint, 2008

Abstract

Background

Translation of the genome sequence of Plasmodium sp. into biologically relevant information relies on high through-put genomics technology which includes transcriptome analysis. However, few studies to date have used this powerful approach to explore transcriptome alterations of

Journal: BMC Genomics, vol. 9, no. Preprint, 2008

Abstract

Background

Recently in a number of studies, it has been demonstrated that the innate immune system doesn't merely acts as the first line of defense but provides critical signals for the development of specific adaptive immune response. Innate immune system employs a set of receptors called pattern

Journal: BMC Genomics, vol. 9, no. Preprint, 2008

Abstract

Background

Cultivated watermelon form large fruits that are highly variable in size, shape, color, and content, yet have extremely narrow genetic diversity. Whereas a plethora of genes involved in cell wall metabolism, ethylene biosynthesis, fruit softening, and secondary metabolism during fruit d

Journal: BMC Genomics, vol. 9, no. Preprint, 2008

Abstract

Background

Much of the morphological diversity in eukaryotes results from differential regulation of gene expression in which transcription factors (TFs) play a central role. The nematode Caenorhabditis elegans is an established model organism for the study of the roles of TFs in controllin

Journal: BMC Genomics, vol. 9, no. Preprint, 2008

Abstract

Background

Independent lines of evidence suggested that a large fraction of human genes possess multiple promoters driving gene expression from distinct transcription start sites. Understanding which promoter is employed in which cellular context is required to unravel gene regulatory networks wit

Journal: BMC Genomics, vol. 9, no. Preprint, 2008

Abstract

Background

Highly fecund mouse strains provide an ideal model to understand the factors affecting maternal performance. The QSi5 inbred strain of mice was selected for high fecundity and low inter-litter interval, and is very successful at weaning large numbers of offspring when compared to other

Journal: BMC Genomics, vol. 9, no. Preprint, 2008

Abstract

Background

Understanding the transcriptional regulation mechanisms in response to environmental challenges is of fundamental importance in biology. Transcription factors associated to response elements and the chromatin structure had proven to play important roles in gene expression regulation. We

Journal: BMC Genomics, vol. 9, no. Preprint, 2008

Abstract

Background

The highest rates of cervical cancer are found in developing countries. Frontline monitoring has reduced these rates in developed countries and present day screening programs primarily identify precancerous lesions termed cervical intraepithelial neoplasias (CIN). CIN lesions described

Journal: BMC Genomics, vol. 9, no. Preprint, 2008

Abstract

Background

Compound microsatellites are a special variation of microsatellites in which two or more individual microsatellites are found directly adjacent to each other. Until now, such composite microsatellites have not been investigated in a comprehensive manner.

Results

Our in silico </

Journal: BMC Genomics, vol. 9, no. Preprint, 2008